Built during C.VII, in 1634 it had been rebuilt together with San Giovanni’s hospital based on a project by Giacomo Mola for the will of Urbano VIII Barberini. In 1730 it was then restored under Benedetto XIII Orsini’s papacy. 

The facade has one part of parastades completed by a gable. The interior has a trapezoidal plan with a nave. The altar niche embodies a Byzantine style fresco coming from the ruins of the church of Santa Maria Imperatrice. One may also admire a particular cosmatesque floor from 1462.